In this paper, we introduce a general numerical method to approximate the reproduction numbers of a large class of multi-group, age-structured, population models with a finite age span.To provide complete flexibility in the definition of the birth and transition processes, we propose an equivalent formulation for the age-integrated state CONDITIONE
Load Balancing Integrated Least Slack Time-Based Appliance Scheduling for Smart Home Energy Management
The emergence of smart devices and smart appliances has highly favored the realization of the smart home concept.Modern smart home systems handle a wide range Cake Plate of user requirements.Energy management and energy conservation are in the spotlight when deploying sophisticated smart homes.However, the performance of energy management systems i
Pre-existing minor variants with NS5A L31M/V-Y93H double substitution are closely linked to virologic failure with asunaprevir plus daclatasvir treatment for genotype 1b hepatitis C virus infection.
BackgroundL31 and Y93 in the NS5A region of the hepatitis C virus (HCV) are the most important substitution positions associated with resistance to direct-acting antiviral (DAA) treatment.MethodsWe analyzed the frequency of NS5A L31M/V and Y93/H in NS5A inhibitor-naive HCV genotype 1 patients who received asunaprevir plus daclatasvir combination tr
Future needs for ship emission abatement and technical measures
Clothing The International Maritime Organization (IMO) has revised air pollution regulations in MARPOL Annex VI.In 2012 Emission Control Areas (ECA) will limit fuel sulphur content to 1% and from 2015 to 0.1%).NOx emissions based on ships engine speed are also reduced for new vessels (2012 & 2016).Facing this legislation, ship owners have the alter